Chemopreventive and antioxidant upshots of Indigofera tinctoria hydromethanolic extract in NPYR induced lung cancer in murine subjects
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چکیده
Indigofera tinctoria is one of the important plants of various traditional medicinal systems. We assessed the effect of hydromethanolic extract of Indigofera tinctoria on biochemical parameters, glutathionemetabolizing enzymes, lung specific markers and glycoproteins in N-nitrosopyrrolidine (NPYR) induced experimental lung toxicity in Swiss albino mice. Experimental subjects bearing lung cancer showed a significant increase in lipid peroxidation (LPO), superoxide dismutase (SOD) activity, total protein content (TPC) and total cholesterol content (TCC). Catalase (CAT) alleviated in NPYR intoxicated mice. Glutathione metabolizing enzymes decreased while lung specific markers-lactate dehydrogenase (LDH), alcohol dehydrogenase (ADH) and γ-glutamyl transpeptidase (GGT) and glycoprotein level increased in NPYR administered mice subjects. Confirmed by histological study, post treatment of low and high doses of I. tinctoria hydromethanolic (ITHML and ITHMH) extract normalizes the abnormal enzymatic and biochemical factors which signify antioxidant and anticancer activity of the plant.
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